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What is Kliovance?

Kliovance tablets are a method of HRT (Hormone Replacement Therapy). These HRT tablets are prescribed for women whose menopause symptoms are so bad that they affect their quality of life.

Kliovance is also prescribed to help prevent osteoporosis in postmenopausal women when other medications aren’t suitable.

Kliovance is prescribed to postmenopausal women who have not had their womb removed and who last had a period over a year ago. There is limited experience of Kliovance being used to treat women over the age of 65.

You should not take Kliovance if:

  • You are allergic to any of the ingredients
  • You have or have ever had breast cancer
  • You have cancer which is sensitive to oestrogens, such as cancer of the endometrium (womb lining)  
  • You are pregnant or breastfeeding
  • You have ever had a blood clot in a vein (thrombosis)
  • You have a blood clotting disorder
  • You have recently had a disease caused by blood clots, such as a stroke, a heart attack, or angina  
  • You have a hereditary blood problem called “porphyria”
  • You have any vaginal bleeding that cannot be explained
  • You have excessive thickening of the womb lining (endometrial hyperplasia) that is not being treated  
  • You have or have previously had liver disease
Read the patient information leaflet fully before taking
Do not store above 25°C
Do not use after expiry date

How does Kliovance work?

The levels of oestrogen and progesterone produced by the female body decrease and fluctuate as a woman ages. These changing hormone levels are what cause menopause and the symptoms that come with it such as hot flushes and mood swings.

Kliovance are combined HRT tablets, which means they contain two female hormones as the active ingredients. These are estradiol, which is an oestrogen, and norethisterone acetate, which is a progestogen. These help to lessen menopause symptoms.

How do you take Kliovance?

It’s important that you take your Kliovance HRT medication exactly how your doctor prescribed to make sure it is as effective as possible. You should also read the patient information leaflet fully before taking this medication.

The usual dose is one tablet every day. You can take your tablet with or without food, but you should swallow it whole with some water. Start a new pack as soon as you finish the pack you are currently taking.

Try to take your tablet at roughly the same time each day, because that way you are less likely to forget to take it. It’s not a problem if you take your tablet late one day, but you should never take a double dose if you forget to take a tablet altogether.

You can start taking Kliovance at any time that works for you. If you are switching to Kliovance from an HRT treatment that gives you a monthly bleed, you should start taking your Kliovance tablets when the bleed finishes.

How effective is Kliovance?

Kliovance HRT tablets are effective at treating symptoms of menopause as long as they are taken as prescribed by your doctor.

Your doctor will aim to have you on the lowest HRT dose for the shortest time possible, since they will want to be sure that the benefits of taking Kliovance outweigh the risks. For this reason it’s important to have regular check-ups, at least annually but more frequently if you feel you need to. You should also have regular breast checks.

To help your HRT treatment work as effectively as possible you can make certain lifestyle changes. These include:

  • Eating a healthy diet
  • Cutting back on alcohol, caffeine and spicy foods
  • Exercising regularly
  • Trying to reduce your stress levels

What are the main side effects of Kliovance?

Like any other medication, Kliovance can cause side effects. Not everyone will experience side effects, however, and they usually only last for the first few months of taking HRT. If you have any concerns about possible side effects, you should see your doctor.

The following conditions occur more frequently in women who are taking HRT than those who aren’t:

  • breast cancer
  • ovarian cancer
  • endometrial hyperplasia / cancer (abnormal growth / cancer of the womb lining)
  • blood clots in the veins of the legs or lungs (venous thromboembolism)
  • heart disease
  • stroke
  • memory loss if HRT is started over the age of 65

Three of the most common side effects of Kliovance are:

  1. Breast pain or tenderness
  2. Vaginal bleeding
  3. Headaches

You may experience some irregular bleeding or spotting in the first 3-6 months of taking Kliovance. This is due to your body adjusting to the medication. If the bleeding continues after 6 months, you should see your doctor.

Taking HRT in the form of tablets (rather than as a patch or gel, for example) can cause an increased risk of developing a blood clot. Your doctor will discuss all the risks with you, but it’s important that you fully understand the risks associated with HRT before you start a course of treatment.   

For a full list of Kliovance side effects, please see the patient information leaflet.

* Disclaimer: Results and individual responses to treatments may vary from person to person. If you do need medical advice you should always speak to a doctor, pharmacist or appropriate medical professional.