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Evorel / Evorel Sequi / Evorel Conti

Evorel / Evorel Sequi / Evorel Conti
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What is Evorel?

Evorel is a medication used for hormone replacement therapy or HRT. It is prescribed to women who are suffering from severe menopause symptoms that are affecting their quality of life.

It can also be used to help prevent osteoporosis in women who have an increased risk of fragile bones since menopause and haven’t had success with other medications.

You should be sure to take the exact dosage your doctor has prescribed for you.

Evorel 25mcg / 50mcg / 75mcg / 100mcg

Evorel 25mcg / 50mcg / 75mcg / 100mcg patches are used in hormone replacement therapy. The patches contain the HRT medication which is slowly absorbed into your body through the skin.

These Evorel patches come in four sizes: Evorel 25, Evorel 50, Evorel 75, Evorel 100. Packs are available of 8, 16 and 24 patches. The patches come in a “memory pack” which is designed to help you remember when to change your patch.

Evorel 50, 75 and 100 can also be used as treatment to help prevent osteoporosis in women who are prone to brittle bones after menopause.

Evorel Sequi

Evorel Sequi patches are used in HRT to lessen symptoms of menopause in women who are finding their quality of life being affected.

There are 8 patches in each pack, which is designed to help you remember when to use a new patch. There are:

  • 4 ‘Evorel 50’ patches containing estradiol only, which are marked CE50
  • 4 ‘Evorel Conti’ patches containing estradiol and norethisterone, which are marked CEN1

The patches are stuck onto the body and the hormones are absorbed through the skin.

Evorel Conti

Evorel Conti patches are a form of HRT medication. The patches are stuck on the skin so the hormones can be absorbed that way.

They come in packs of 8 or 24 patches and the pack is designed to help you remember when you need a new patch.

How does Evorel work?

As women grow older, they produce less of the hormones oestrogen and progesterone. This is what causes menopause and brings about symptoms such as hot flushes, mood swings and night sweats.

Evorel patches replace one or both of these hormones to help alleviate menopause symptoms.

It is important to remember that these HRT products are NOT contraceptives.

Evorel 25mcg / 50mcg / 75mcg / 100mcg

Evorel patches contain estradiol, which replaces the female hormone oestrogen usually released by the ovaries. This helps to regulate any fluctuating levels of oestrogen and control menopausal symptoms.

If you still have a womb, your doctor will have prescribed this alongside a progestogen product to cancel out the increased risk of womb cancer that comes with taking an oestrogen-only HRT product.  

Evorel Sequi

Evorel Sequi patches are known as continuous sequential HRT. This is because the two active ingredients, estradiol (an oestrogen) and norethisterone (a progestogen), are used in sequence, one after the other.

Patches containing estradiol only are used for two weeks, followed by patches containing both estradiol and norethisterone for a further two weeks.

These replace the natural hormones in the body and help to relieve menopause symptoms. You will also likely experience a withdrawal bleed, like a period, in the fourth week of your Evorel Sequi pack.

Evorel Conti

Evorel Conti is called continuous combined HRT, meaning that the two hormones in these patches are released all the time.

The following two active ingredients are in Evorel Conti patches: estradiol (an oestrogen) and norethisterone (a progestogen). These replace the natural hormones in the body and help to alleviate the menopause symptoms.

Most women won’t have any withdrawal bleeding with Evorel Conti. There may be some spotting in the first few months of using these patches as your body adapts to your new treatment.

How do you use Evorel?

It’s important that you use Evorel patches in exactly the way your doctor has prescribed.

You should read the patient information leaflet in full before you begin using your HRT patches.

You can bath or shower as normal when using any of the Evorel patches. You can also go swimming and exercise, just avoid wearing your patch under tight clothing or your waistband. If you’re sunbathing, you should be careful to keep the patch covered and out of direct sunlight.

Evorel 25mcg / 50mcg / 75mcg / 100mcg

Make sure you use the Evorel patches that your doctor has prescribed since each kind contains a different dosage of estradiol. The maximum dosage you should use in a day is 100 micrograms. This is the daily dosage of estradiol in the Evorel 100mcg patch.

When to start using Evorel:

  • You can start using Evorel at any time if you have never used HRT and no longer have periods, your periods aren’t regular and you aren’t pregnant, or if you’re changing from a form of HRT that doesn’t give you a withdrawal bleed.
  • If you are not currently taking HRT and are still having regular periods, you should start using Evorel within 5 days of the start of bleeding.
  • If you are changing from a HRT medicine that gives you a withdrawal bleed, you should use your first patch at the end of a treatment cycle or one week after.

You should change your patch twice a week and start a new pack of patches as soon as you’ve finished the previous pack. You should change your patch on the same two days each week, depending on the day you started using the patches:

  • Monday and Thursday
  • Tuesday and Friday
  • Wednesday and Saturday
  • Thursday and Sunday
  • Friday and Monday
  • Saturday and Tuesday
  • Sunday and Wednesday

Apply the patch to an area of clean and dry hairless skin below the waist and never on the upper body. Many women like to stick their HRT patch on their thigh or bottom.

Evorel Sequi

You begin a pack of Evorel Sequi patches by using an Evorel 50 patch. The four Evorel 50 patches are used one at a time for two weeks. Then for the following two weeks, when the four Evorel 50 patches are used, you use the four Evorel Conti patches one after another.

You should start a new pack of patches as soon as one pack is used, following the same process as above for each pack.

When to start using Evorel Sequi:

  • You can start using Evorel Sequi at any time if you have never used HRT and no longer have periods, your periods aren’t regular and you aren’t pregnant, or if you’re changing from a form of HRT that doesn’t give you a withdrawal bleed.
  • If you are not currently taking HRT and are still having regular periods, you should start using Evorel within 5 days of the start of bleeding.
  • If you are changing from a HRT medicine that gives you a withdrawal bleed, you should use your first patch at the end of a treatment cycle or one week after.

You should change your patch twice a week, on the same two days each week. The two days you change your patch depend on the day you started using the patches:

  • Monday and Thursday
  • Tuesday and Friday
  • Wednesday and Saturday
  • Thursday and Sunday
  • Friday and Monday
  • Saturday and Tuesday
  • Sunday and Wednesday

Stick the patch to an area of clean, dry hairless skin below the waist. It should never be placed on the upper body. Many women prefer to stick their patch to their thigh or bottom.

Evorel Conti

When to start using Evorel Conti:

  • If you’ve never used HRT before you can start using Evorel Conti at any time.
  • If you are changing from an HRT medicine that gives you a withdrawal bleed, you should use your first patch at the end of a treatment cycle or one week after.

You should change your patch twice a week, on the same two days each week. The two days you change your patch depend on the day you started using the patches:

  • Monday and Thursday
  • Tuesday and Friday
  • Wednesday and Saturday
  • Thursday and Sunday
  • Friday and Monday
  • Saturday and Tuesday
  • Sunday and Wednesday

Make sure you start your new pack of patches as soon as you finish the pack you’re using. There should be no break.

Stick the patch to an area of clean, dry hairless skin below the waist, not on the upper body. Many women prefer to stick their patch to their thigh or bottom.

Things you need to know before taking Evorel 25mcg/50mcg/75mcg/100mcg, Evorel Sequi or Evorel Conti

It’s important that you talk to your doctor and fully understand the risks and benefits of HRT before you begin a course of treatment.

You should also make sure you have regular check-ups with your GP, to make sure your Evorel HRT treatment is working well. Your doctor will aim to have you on the lowest dosage for the shortest time possible, so long as your symptoms are well managed.  

You shouldn’t use Evorel 25mcg / 50mcg / 75mcg / 100mcg, Evorel Sequi or Evorel Conti if:

  • You’re allergic to any of the ingredients in the patches
  • You currently have or have ever had breast cancer
  • You have, or have ever had, a cancer made worse by oestrogens (endometrial cancer for example)
  • You have a thickening of the womb lining that isn’t being treated
  • You have unexplained vaginal bleeding
  • You have ever had blood clots
  • You have problems with the blood that might increase the likelihood of a blood clot (for example protein C, protein S or antithrombin deficiency)
  • You have, or have ever had, liver disease
  • You have ever had blocked arteries that gave you angina, a heart attack or a stroke
  • You have the often hereditary blood problem called porphyria.

If you are going to have surgery, you should make sure your doctor is aware that you’re taking HRT since it may be necessary to stop taking your treatment in the weeks leading up to your operation.

What are the main side effects of Evorel?

Like any other medication, Evorel patches can cause side effects. Not everyone will experience side effects, however, and they’re usually temporary with HRT. If you have any concerns about side effects you may be experiencing you should see your doctor.

The following conditions are reported more commonly amongst women who are taking HRT than those who aren’t:

  • breast cancer
  • endometrial hyperplasia / cancer (abnormal growth / cancer of the womb lining)
  • ovarian cancer
  • blood clots in the veins of the legs or lungs (venous thromboembolism)
  • heart disease
  • stroke
  • probable memory loss if HRT is started over the age of 65

Evorel 25mcg / 50mcg / 75mcg / 100mcg

Three of the most common side effects for Evorel 25mcg / 50mcg / 75mcg / 100mcg are:

  1. Irritated, itchy skin, a rash or puffy skin where the patch is applied
  2. Breast pain
  3. Dizziness

For a full list of Evorel HRT patches side effects, please see the patient information leaflet.

Evorel Sequi

Three of the most common side effects for Evorel Sequi are:

  1. Itchy, irritated or red skin where the patch is applied
  2. Depression or anxiety
  3. Becoming overly emotional

For a full list of Evorel Sequi HRT side effects, please see the patient information leaflet.

Evorel Conti

Three of the most common side effects for Evorel Conti are:

  1. Red, irritated or itchy skin where the patch is applied
  2. Allergic reaction
  3. Not being able to sleep

For a full list of Evorel Conti HRT patches side effects, please see the patient information leaflet.

* Disclaimer: Results and individual responses to treatments may vary from person to person. If you do need medical advice you should always speak to a doctor, pharmacist or appropriate medical professional.