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Epiduo Gel

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What is Epiduo Gel?

Epiduo gel is used to treat acne. Epiduo acne treatment is a topical (applied directly to the skin) medication. Epiduo helps clear up active breakouts and prevents future pimples from forming. This medication can be taken alongside an oral acne treatment.

How does Epiduo Gel work?

Epiduo has two active ingredients, adapalene and benzoyl peroxide. Adapalene is from a family of medicines called retinoids. Retinoids act on the skin processes that cause acne, while benzoyl peroxide is an antimicrobial agent that softens and peels the outer layer of the skin.  

How do you use Epiduo Gel?

Always use this medication exactly as it has been prescribed to you.


Apply a thin layer of Epiduo Gel evenly over acne affected areas once a day at bedtime. Avoid the eyes, lips and nostrils. Use Epiduo daily for as long as your doctor or pharmacist has prescribed.


Ensure that your skin is clean and dry before application. It is important to wash your hands after application.


It can take 4-6 weeks to see results.


Acne medications containing benzoyl peroxide may bleach your clothing and hair.

How effective is Epiduo Gel?

Adapalene benzoyl peroxide combinations are an effective way of treating acne.

What are the main side effects of Epiduo Gel?

Like all medicines, Epiduo Gel can cause side effects. Side effects are typically mild and only last a short period of time. The most common side effects of Epiduo Gel are:

  • Dry skin
  • Local skin rash (irritative contact dermatitis)
  • Burning sensation

For a list of less frequent side effects, please see the patient information leaflet.

Frequently Asked Questions

How long does it take for Epiduo to work?


Topical acne creams can take some time to work. While you might see results in the first few weeks, Epiduo Gel typically takes about 4-6 weeks to produce results.


Is Epiduo safe?


Epiduo is safe to use if prescribed by a doctor or pharmacist. You should not use this medication with any other topical treatments unless advised by your doctor or pharmacist.


What is a retinoid?


Retinoids are medicines that act on the processes that cause acne to treat and prevent breakouts.


Does Epiduo contain antibiotics?


No, Epiduo is the only treatment with a fixed dose combination of 0.1% adapalene and 2.5% benzoyl peroxide that does not also contain an antibiotic.

More Information
Dosage No
Dosage Instructions Apply thinly ONCE every evening.